Validation of transient elastography in autoimmune hepatitis: timing determines the impact of inflammation and fibrosis

2016 Journal of Hepatology In press;

BACKGROUND: There is an unmet need for the non-invasive monitoring of fibrosis progression in patients with autoimmune hepatitis (AIH). AIMS: To assess the diagnostic performance of transient elastography in patients with AIH and to investigate the impact of disease activity on its diagnostic accuracy. METHODS: Optimal cut-offs were defined in a prospective pilot-study (n=34) and the diagnostic performance of transient elastography validated in an independent second cohort (n=60). To explore the impact of disease activity on liver stiffness, patients were stratified according to biochemical response and the time interval between start of immunosuppression and transient elastography. RESULTS: Liver stiffness strongly correlated with histological fibrosis stage (pilot-study: rho = 0.611, p

Pubmed : 27238753