Transient liver elastography in unsedated control children: Impact of age and intercurrent illness

2016 Journal of Paediatrics and Child Health 52;6 (637-642)

AIM: Transient elastography (TE) is a rapid, non-invasive, reproducible assessment of liver fibrosis by liver stiffness measurement (LSM). Uncertainty remains regarding utility in children, unsedated and 2 years reliable results were obtained in ~80%. LSM increased with age; 0-2 years (3.5 +/- 0.5 kPa), 3-5 years (3.8 +/- 0.3 kPa) and 6-11 years (4.1 +/- 0.2 kPa) with healthy older children 12-18 years similar to adults (4.5 +/- 0.2 kPa). LSM did not vary with gender (female, 4.5 +/- 0.2 vs. male, 4.8 +/- 0.2 kPa). Children with intercurrent, non-hepatological illnesses had higher LSM (5.2 +/- 0.2 kPa (range, 2.8-11.1 kPa)) compared to healthy children ((4.1 +/- 0.1 kPa, range, 2.1-6.3 kPa); P = 0.0001). CONCLUSIONS: TE in unsedated children is feasible from infancy but most reliable after 2 years. Intercurrent illness increases LSM; hence, study context is important when interpreting results.

Pubmed : 27203205