Transient elastography for predicting esophageal/gastric varices in children with biliary atresia

2011 BMC Gastroenterology 11;1 (41)

BACKGROUND: Transient elastography (TE) is an innovative, noninvasive technique to assess liver fibrosis by measuring liver stiffness in patients with chronic liver diseases. The purpose of this study has been to explore the accuracy of TE and clinical parameters in predicting the presence of esophageal/gastric varices in children with biliary atresia (BA) following portoenterostomy. METHODS: Patients with BA status post portoenterostomy and normal children were recruited. Splenomegaly and presence of EV/GV were determined by physical examination and endoscopy, respectively. Aspartate transaminase to platelet ratio index (APRI) was used as a serum fibrosis marker. TE was performed by using FibroScan. Data was expressed as mean +/- SD. RESULTS: Seventy-three BA patients (male:female = 32:41; age 9.11 +/- 5.64 years) and 50 normal controls (male:female = 19:31; age 11.00 +/- 3.31 years) were enrolled. The liver stiffness score of BA patients was significantly higher than that of normal controls (27.37 +/- 22.48 and 4.69 +/- 1.03 kPa; p

Pubmed : 21501480