Transient Elastography-Based Liver Profiles in a Hospital-Based Pediatric Population in Japan

2015 PLoS ONE 10;9 (e0137239)

BACKGROUND & AIMS: The utility of transient elastography (FibroScan) is well studied in adults but not in children. We sought to assess the feasibility of performing FibroScans and the characteristics of FibroScan-based liver profiles in Japanese obese and non-obese children. METHODS: FibroScan examinations were performed in pediatric patients (age, 1-18 yr) who visited Osaka City University Hospital. Liver steatosis measured by controlled attenuation parameter (CAP), and hepatic fibrosis evaluated as the liver stiffness measurement (LSM), were compared among obese subjects (BMI percentile >/=90%), non-obese healthy controls, and non-obese patients with liver disease. RESULTS: Among 214 children examined, FibroScans were performed successfully in 201 children (93.9%; median, 11.5 yr; range, 1.3-17.6 yr; 115 male). CAP values (mean+/-SD) were higher in the obese group (n = 52, 285+/-60 dB/m) compared with the liver disease (n = 40, 202+/-62, P

Pubmed : 26398109