[The efficacy of transient liver elastography overweight patients with chronic liver diseases]

2010 Eksperimental Klinical Gastroenterology 5 (19-26)

Transient elastography (TE) allows evaluating the liver fibrosis stage indirectly and noninvasively. High correlation between results with liver fibrosis stage was shown previously. It was suggested that availability and reproducibility of the method is low in patients with excessive. AIM: To evaluate availability, reproducibility and diagnostic accuracy of transient elastography in patients with different body mass index (BMI) and liver fibrosis stage. MATERIALS AND METHODS: Two hundred patients with chronic liver diseases (predominantly with chronic hepatitis C, n = 135) were enrolled. Among them 100 were included to the group with BMI > or = 25 kg/m2 (M +/- m 29,58 +/- 3,7 kg/m2) and 100 patients with BMI 30%) per group. The reproducibility of TE was studied by counting intra-observer agreement (correlation between results of two series by 11 measurements obtained during examination of the patient) and inter-observer agreement between the results of examinations of the patient by two independent skilled operators obtained on the same day. Diagnostic accuracy was estimated using concordance of the results of liver histology and TE with following cut-off values: 5.8 kPa for F0, 7.2 kPa for F2, 9.5 kPa for F3 and 12.5 kPa for F4. RESULTS: Availability of TE was lower for patients with BMI > or = 25 kg/m2: 87,13% vs 99% (BMI or = 25 kg/m2, and 0.990095% [0.9851 -0.9931] for patients with BMI or = 25 kg/m2 (0.987, 95% CI [0.981 -0.990]) then in group with BMI

Pubmed : 20731131