The accuracy of spleen stiffness measurement to predict varices in chronic hepatitis B cirrhotic patients with or without taking non-selective beta-blockers

2016 Journal of Digestive Diseases In press;

BACKGROUND & AIMS: The accuracy of liver and spleen stiffness measurement (LSM & SSM) with transient elastography to predict varices in the presence of non-selective beta-blockers (NSBB) has never been studied before. METHODS: This was a cross-sectional study of consecutive patients with chronic hepatitis B (CHB) and cirrhosis. All patients underwent transient elastography and upper endoscopic examinations. Performance of LSM and SSM to predict varices in patients did and did not receive NSBB was evaluated. RESULTS: 144 CHB patients (29 received NSBB; 35 had any varices, 31 and 11 had esophageal and gastric varices respectively) were recruited. The mean LSM and SSM were 19.7 +/- 10.1 kPa and 24.8 +/- 7.2 kPa respectively. The correlation between LSM and SSM was better in NSBB subgroup (r = 0.525, P = 0.003) than its counterpart (r = 0.329, P

Pubmed : 27185358