Serum retinol binding protein 4 and clinical outcome in postoperative biliary atresia

2011 Hepatology International 5;4 (906-912)

BACKGROUND: Biliary atresia (BA), a chronic inflammatory disease of bile ducts, is characterized by the obliteration of bile flow. The aim of the present study was to investigate serum retinol binding protein 4 (RBP4) in postoperative BA patients and the association of RBP4 with clinical parameters and liver stiffness scores. METHODS: A number of forty-eight BA patients post Kasai operation and 24 controls were enrolled. None of the patients had undergone liver transplantation. BA patients were classified into two groups according to their serum total bilirubin (TB) levels (non-jaundice, TB /= 2 mg/dl) and liver stiffness (insignificant fibrosis, liver stiffness /=7 kPa). Serum RBP4 levels were determined by enzyme-linked immunosorbent assay (ELISA). Liver stiffness scores were measured by FibroScan. RESULTS: BA patients had lower RBP4 levels (14.9 +/- 1.0 vs. 18.7 +/- 1.0 ng/ml, P = 0.02), but higher liver stiffness than controls (29.5 +/- 3.3 vs. 5.0 +/- 0.5 kPa, P

Pubmed : 21484122