Serum adiponectin and transient elastography as non-invasive markers for postoperative biliary atresia

2011 BMC Gastroenterology 11;(16)

BACKGROUND: Biliary atresia (BA) is a progressive inflammatory disorder of the extrahepatic bile ducts leading to the obliteration of bile flow. The purpose of this study was to determine serum adiponectin in BA patients and to investigate the relationship of adiponectin with clinical parameters and liver stiffness scores. METHODS: Sixty BA patients post Kasai operation and 20 controls were enrolled. The mean age of BA patients and controls was 9.6 +/- 0.7 and 10.1 +/- 0.7 years, respectively. BA patients were classified into two groups according to their serum total bilirubin (TB) levels (non-jaundice, TB /= 2 mg/dl) and liver stiffness (insignificant fibrosis, liver stiffness /= 7 kPa). Serum adiponectin levels were analyzed by enzyme-linked immunosorbent assay. Liver stiffness scores were examined by transient elastography (FibroScan). RESULTS: BA patients had markedly higher serum adiponectin levels (15.5 +/- 1.1 vs. 11.1 +/- 1.1 mug/ml, P = 0.03) and liver stiffness than controls (30.1 +/- 3.0 vs. 5.1 +/- 0.5 kPa, P

Pubmed : 21356120