Relationship between liver fibrosis noninvasively measured by FibroScan and blood test

2007 Bulletin of the Osaka Medical College 2, 53 (93-105)

Recently, Fibro scan was developed as a non-invasive device for measuring liver fibrosis. Progression of liver fibrosis has been reported to increase the measurement value (elasticity). We have performed the Fibro scan for liver diseases.[ ;normal liver (n=33), hepatitis C (n=156), hepatitis B(n=36), non-alcoholic fatty liver disease (n=24), auto immune hepatitis (n=9), primary biliary cirrhosis (n=10), alcoholic liver disease (n=7), acute hepatitis (n=3), other liver disease (n=14), recipient of living donor liver transplantation (n=11)] Elasticity, blood test, and indirect fibrosis diagnostic score were comparatively investigated. In the hepatitis C group, the mean value for elasticity was 14.7±12.0 kPa. Elasticity was found to be significantly correlated with the hepatobiliary enzymes, fibrosis markers and indirect fibrosis diagnostic score. When elasticity was divided into ?14.6kPa(liver cirrhosis) and<14.6kPa(non liver cirrhosis) groups for the investigation, liver inflammation and fibrosis markers were correlated in the progress of fibrosis in non liver cirrhosis, and it could be speculated that if liver cirrhosis is reached, progression of fibrosis reflects decreased liver function.