Noninvasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores

2012 Scandinavian Journal of Gastroenterology 47;11 (1353-1361)

Abstract Objective. Noninvasive investigation of liver fibrosis with ultrasound-based elastography and laboratory-based fibrosis indices have been established in various chronic liver diseases within the last years. We aimed to evaluate feasibility and diagnostic value of transient elastography (TE), acoustic radiation force impulse imaging (ARFI), and different serologic fibrosis indices in Wilson's disease (WD). Materials and methods. TE and ARFI were performed in 50 Wilson patients. In addition, AST/Platelet Ratio Index (APRI), FIB-4, and Forns score were calculated. Hepatic fibrosis was classified by a clinical score. Results. Of the 50 Wilson patients 41 had hepatic manifestation of WD. TE results were significantly increased in advanced hepatic fibrosis (7.0 +/- 2.2 kPa; p 0.33; p