Non-invasive assessment of liver fibrosis in chronic viral hepatitis

2015 European Journal of Clinical Investigation 45;12 (1243-1251)

BACKGROUND: Hyaluronic acid (HA), ASAT to Platelet Ratio Index (APRI), ASAT/ALAT ratio, Fibrosis 4 score (FIB4) and FibroScan were studied as non-invasive markers of liver fibrosis (F) in chronic viral hepatitis B (CHB) and C (CHC), in an attempt to avoid the complications of liver puncture biopsy, considered the gold standard in the evaluation of F. The aim of our research was to study whether HA, APRI, ASAT/ALAT ratio, FIB4 and FibroScan are useful non-invasive markers in predicting severe F in Romanian patients. PATIENTS AND METHODS: This was a prospective multicenter transversal and observational study, which included 76 patients with CHB/CHC. The independent effect of studied markers was tested using multiple binary logistic regression. RESULTS: In patients with CHB and CHC, the APRI cut-off value for F4 was 0.70 ng/mL (Se = 77%, Sp = 78%), the FIB4 cut-off value was 2.01 (Se = 77%, Sp = 69%), and the FibroScan cut-off value was 13.15 (Se = 92%, Sp = 88%). For patients with CHB/CHC, there was a significant linear positive correlation between F and HA (r = 0.42, P = 0.001), FibroScan (r = 0.67, P

Pubmed : 26426402