Multiparametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease severity

2017 Liver International 37;7 (1065-1073)

BACKGROUND & AIMS: The diagnosis of non-alcoholic steatohepatitis and fibrosis staging are central to non-alcoholic fatty liver disease assessment. We evaluated multiparametric magnetic resonance in the assessment of non-alcoholic steatohepatitis and fibrosis using histology as standard in non-alcoholic fatty liver disease. METHODS: Seventy-one patients with suspected non-alcoholic fatty liver disease were recruited within 1 month of liver biopsy. Magnetic resonance data were used to define the liver inflammation and fibrosis score (LIF 0-4). Biopsies were assessed for steatosis, lobular inflammation, ballooning and fibrosis and classified as non-alcoholic steatohepatitis or simple steatosis, and mild or significant (Activity >/=2 and/or Fibrosis >/=2 as defined by the Fatty Liver Inhibition of Progression consortium) non-alcoholic fatty liver disease. Transient elastography was also performed. RESULTS: Magnetic resonance success rate was 95% vs 59% for transient elastography (P<.0001 fibrosis stage on biopsy correlated with liver inflammation and p the area under receiver operating curve using for diagnosis of cirrhosis was score ballooning grades respectively an characteristic ballooning. patients steatosis had lower compared to non-alcoholic steatohepatitis scores mild significant fatty disease were conclusions: multiparametric magnetic resonance is a promising technique good diagnostic accuracy histological parameters can potentially identify cirrhosis. class="article_links">

Pubmed : 27778429