Liver Stiffness-Spleen Size-to-Platelet Ratio Risk Score Identifies Esophageal Varices in Japanese Patients with Chronic Hepatitis C

2015 Hepatology Research In press;

AIM: Noninvasive methods are needed to identify esophageal varices (EV) in patients with chronic liver disease. To this end, we evaluated liver stiffness (LS)-spleen diameter-to-platelet ratio risk score (LSPS) in predicting EV among Japanese chronic hepatitis C patients. METHODS: A total of 99 patients with chronic hepatitis C who had undergone endoscopy, LS measurement, and ultrasonography between 2012 and 2014 were enrolled. Clinical data were compared with those for other noninvasive markers (platelet count, aspartate aminotransferase-to-platelet ratio, FIB-4 index, and platelet-to-spleen ratio), spleen size, LS, and controlled attenuation parameter. Diagnostic applicability was assessed by the area under the receiver operating characteristic curve and predictive values along with multivariate logistic regression. RESULTS: LSPS was significantly correlated to the grade of EV (rho = 0.617, P

Pubmed : 26662612