Liver stiffness measurement in combination with noninvasive markers for the improved diagnosis of B-viral liver cirrhosis

2009 Journal of Clinical Gastroenterology 43;3 (267-271)

GOAL: To investigate the performance of liver stiffness measurement (LSM) in combination with available noninvasive markers in hepatitis B virus-related chronic liver disease. BACKGROUND: Few noninvasive methods are available for predicting liver cirrhosis in chronic hepatitis B (CHB). STUDY: Between January 2006 and June 2007, we studied 130 consecutive treatment-naive CHB patients who underwent liver biopsy (LB) and LSM. The aspartate to alanine aminotransferase ratio, age-platelet index (API), aspartate aminotransferase to platelet ratio index (APRI), LSM, and their combinations were compared with liver histology. RESULTS: The API, APRI, and LSM, but not the aspartate to alanine aminotransferase ratio, correlated significantly with liver cirrhosis (all P

Pubmed : 18987556