Late graft hepatitis and fibrosis in pediatric liver allograft recipients: Current concepts and future developments

2016 Liver Transplantation 22;11 (1593-1602)

Liver transplantation (LT) in children now has a 20-year survival of >80%, but the longterm outcome of these grafts remains uncertain. Serial protocol liver biopsies after transplantation from several pediatric centres have demonstrated the gradual development of unexplained graft inflammation (idiopathic" posttransplant hepatitis