Impact of anthropometric features on the applicability and accuracy of FibroScan((R)) (M and XL) in overweight/obese patients

2017 Journal of gastroenterology and hepatology 32;10 (1746-1753)

BACKGROUND AND AIM: Transient elastography is the reference method for liver stiffness measurement (LSM) in the general population, having lower applicability in obese patients. We evaluated the applicability and diagnostic accuracy of the M and XL probes in overweight/obese patients to establish the most appropriate approach. METHODS: From May 2013 to March 2015, we evaluated patients with a body mass index (BMI) >/= 28 kg/m(2) . We constructed an algorithm with variables independently related to unreliable LSM with the M probe. RESULTS: A total of 1084 patients were evaluated. M and XL probe applicability was 88.8% and 98%, respectively. Waist circumference (WC) (OR; 95% CI; P) (0.97; 0.94-0.99; P 25 mm in 5.5% of individuals with a BMI = 35 kg/m(2) and a WC = 117 cm, with LSM (M probe) applicability rising to 94.3%. In contrast, 36.9% of patients with a BMI > 35 kg/m(2) and/or a WC > 117 cm presented an SCD > 25 mm, with M probe applicability being 73.1%. The diagnostic accuracy (area under the receiver operator characteristic) using the M probe to identify significant steatosis (0.76), fibrosis (0.89), and cirrhosis (0.96) was very high in patients with a BMI = 35 kg/m(2) and a WC = 117 cm. CONCLUSIONS: The applicability and accuracy of the FibroScan((R)) M probe to identify fibrosis and steatosis was excellent in overweight and obesity grade I (BMI = 35 kg/m(2) ) with a WC = 117 cm. The XL probe increased the applicability of transient elastography in obesity grade II-III (BMI > 35 kg/m(2) ).

Pubmed : 28201854