High serum matrix metalloproteinase-3 and liver stiffness in postoperative biliary atresia

2011 Pediatric Surgery International 27;7 (681-687)

BACKGROUND: Biliary atresia (BA) is a neonatal liver disorder characterized by chronic inflammation and obliteration of extrahepatic bile ducts. The purpose of the study was to investigate serum matrix metalloproteinase-3 (MMP-3) in postoperative BA patients and the association of MMP-3 with clinical outcome and liver stiffness score. METHODS: Fifty-eight BA patients post-Kasai operation and 20 controls were enrolled. None of the patients had undergone liver transplantation. BA patients were classified into two groups according to their serum total bilirubin (TB) levels (TB /= 2 mg/dL, persistent jaundice) and alanine aminotransferase (ALT) levels (ALT /= 45 IU/L, elevated ALT). Serum MMP-3 levels were determined by enzyme-linked immunosorbent assay. Liver stiffness scores were measured by FibroScan. RESULTS: BA patients had greater MMP-3 levels (10.8 +/- 1.0 vs. 7.9 +/- 0.8 ng/mL, P = 0.02) and higher liver stiffness values than controls (29.7 +/- 3.0 vs. 5.1 +/- 0.5 kPa, P

Pubmed : 21191599