Fibroscan: a new noninvasive method for evaluation of liver dysfunction in Turner syndrome

2011 European Journal of Clinical Investigation 41;2 (183-188)

BACKGROUND: Raised liver enzyme value is frequently detected in patients with Turner syndrome (TS), but its clinical importance is still unclear. OBJECTIVE: To investigate the entity of liver involvement in TS and to avoid the invasiveness of liver biopsy, we planned to measure liver stiffness by transient elastography (TE). DESIGN: Cross-sectional study. PATIENTS AND METHODS: Twenty-five consecutive patients with TS and a chronological age >/= 12.5 years (mean age = 21.7 years), full pubertal development and final height's achievement were enrolled and investigated by blood biochemical analyses [glucose, insulin, aspartate-aminotransferase (AST), alanine-aminotransferase (ALT), gamma-glutamil transferase (GGT), alkaline phosphatase, cholesterol, triglyceride, HDL-cholesterol], ultrasonography and TE of the liver. RESULTS: Of 25, 7 subjects (28%) showed liver enzyme levels higher than the normal upper limit. Mean liver stiffness value in the entire study group was 4.5 +/- 1.7 kPa, being significantly higher in patients with abnormal liver enzymes than in those with normal liver biochemistry (6.0 +/- 2.9 vs. 4.0 +/- 0.9, P

Pubmed : 20964679