Factors influencing reliability of liver stiffness measurements using transient elastography (M-probe)-monocentric experience

2013 European Journal of Radiology 82;8 (e313-316)

AIM: To retrospectively assess the feasibility of transient elastography (TE) and the factors associated with failed and unreliable liver stiffness measurements (LSMs), in patients with chronic liver diseases. MATERIAL AND METHODS: Our retrospective study included 8218 consecutive adult patients with suspected chronic liver diseases. In each patient, LSMs were performed with a FibroScan((R)) device (Echosens, France), with the M probe. Failure of TE measurements was defined if no valid measurement was obtained after at least 10 shots and unreliable if fewer than 10 valid shots were obtained, success rate (SR) /=30%. RESULTS: From the 8218 patients, failed and unreliable LSMs were observed in 29.2% of cases. In univariant analysis, the following risk factors were associated with failed and unreliable measurements: age over 50 years (OR 2.04; 95%CI 1.84-2.26), female gender (OR 1.32; 95%CI 1.20-1.45), BMI>27.7kg/m(2) (OR 2.89, 95%CI 2.62-3.19), weight>77kg (OR 2.17; 95%CI 1.97-2.40) and height27.7kg/m(2), heavier than 77kg and shorter than 162cm), the rate of failed and unreliable measurements was 58.5%. In obese patients (BMI>/=30kg/m(2)), the rate of failed and unreliable measurements was 49.5%. CONCLUSION: Failed and unreliable LSMs were observed in 29.1% of patients. Female gender, older age, higher BMI, higher weight and smaller height were significantly associated with failed and unreliable LSMs.

Pubmed : 23562532