Elevation of serum galectin-3 and liver stiffness measured by transient elastography in biliary atresia

2011 European Journal of Pediatric Surgery 21;4 (250-254)

BACKGROUND AND AIM: Biliary atresia (BA) is an intractable neonatal liver disease characterized by progressive fibrosclerotic obliteration of the extrahepatic biliary tree. The aim of this study was to evaluate serum galectin-3 in postoperative BA patients and the association between galectin-3, clinical outcome and liver stiffness score. METHODS: 58 BA patients post Kasai operation and 20 controls were enrolled. None of the patients had undergone liver transplantation. BA patients were classified into 2 groups according to their serum total bilirubin (TB) levels (TB/=2 mg/dL, persistent jaundice) and alanine aminotransferase (ALT) levels (ALT/=45 IU/L, elevated ALT). Serum galectin-3 levels were determined by enzyme-linked immunosorbent assay. Liver stiffness scores were measured by transient elastography (FibroScan). RESULTS: BA patients had higher serum galectin-3 levels (5.1+/-0.3 vs. 3.8+/-0.4 ng/mL, p=0.01) and greater liver stiffness values than healthy controls (29.7+/-3.0 vs. 5.1+/-0.5 kPa, p

Pubmed : 21487991