Elastography of shear wave speed imaging for the evaluation of liver fibrosis: a meta-analysis

2016 Hepatology Research In press;

BACKGROUND & AIMS: A meta-analysis was performed to assess the accuracies of shear wave speed imaging (SWSI) in predicting significant fibrosis (stage F2-4) and cirrhosis (stage F4). METHODS: Literature review was studied from early stages up to October 2015. A bivariate binomial model was used to combine the sensitivity, specificity and the area under the summary receiver operating characteristic (AUC) and the 95% confidence intervals (95% CI) were derived to indicate the diagnostic accuracy of imaging modalities. RESULTS: In total, ten studies with 2182 patients were included. The sensitivity, specificity, and AUC (with 95% CI) of SWSI were 0.84 (0.81-0.87), 0.83 (0.77-0.88), and 0.88 (0.85-0.90) for significant fibrosis, respectively; were 0.80 (0.66-0.89), 0.93 (0.88-0.96), and 0.95 (0.92-0.96) for cirrhosis, respectively. When compared SWSI with well evaluated transient elastography (TE), the AUCs for the prediction of significant fibrosis were 0.93 and 0.86, respectively. Meanwhile, the AUCs for the prediction of cirrhosis were both 0.94. CONCLUSIONS: SWSI is trustworthy tool for staging hepatic fibrosis, with a high combination of sensitivity and specificity. Compared with TE, SWSI showed better diagnostic performance for the prediction of significant fibrosis.

Pubmed : 26857658