Effect of antioxidant therapy on hepatic fibrosis and liver iron concentrations in beta-thalassemia major patients

2013 Hemoglobin 37;3 (257-276)

To assess the effects of combined vitamin therapy on oxidant-antioxidant hepatic status and hemoglobin (Hb) derivatives on beta-thalassemia major (beta-TM), a prospective study of 60 beta-TM patients aged 4 to 17 years, was conducted. Thirty-nine patients with initial low serum vitamins E, C and A, were treated with oral combined vitamins for 1 year compared to 21 patients with normal vitamin levels. Serum transaminases, serum ferritin, hepatic fibroscan elastography (TE) and magnetic resonance imaging R2* (MRI R2*) for liver iron concentration (LIC), were assessed before and after 6 and 12 months of therapy. Antioxidant capacity was assessed by levels of reduced glutathione (GSH), malondialdehyde (MDA), catalase, superoxide dismutase and GSH enzymes. The studied vitamins, reduced GSH and Hb levels were significantly elevated and paralleled by progressive decline in MDA and ferritin during therapy (p 12 kPa) at baseline compared to 20.5% after therapy (p >0.05), although LIC values were significantly decreased (p

Pubmed : 23565660