Dynamics of the liver stiffness value using transient elastography during the perioperative period in patients with valvular heart disease

2014 PLoS ONE 9;3 (e92795)

BACKGROUND/AIMS: Liver congestion due to heart failure in patients with valvular heart disease (VHD) can result in an overestimate of the liver stiffness (LS) as assessed by transient elastography (TE). This prospective pilot study investigated the dynamics of LS during the perioperative valve operation period. METHODS: Thirty-two patients who underwent a valve operation (case) and 12 who underwent a varicose vein operation (control) were prospectively enrolled. LS and cardiologic parameters at three time points [baseline, post-operative day (POD)7, and POD90] were collected. RESULTS: LS at three time points were consistently higher in the case group than those in the control group, although all participants did not show evidence of underlying chronic liver disease (all P8.4 kPa, P = 0.816), whereas LS at POD90 decreased significantly from the LS at POD7 (median 8.4-->6.0 kPa; P = 0.026). LS was significantly correlated with N-terminal-pro brain natriuretic peptide (NT-proBNP) (rho = 0.412), left ventricular ejection fraction (rho = -0.494), and central venous pressure during the operation (rho = 0.555) at baseline (all P

Pubmed : 24670988