Diagnostic value of real-time elastography in the assessment of hepatic fibrosis in patients with liver iron overload

2013 European Journal of Radiology 82;12 (e755-761)

OBJECTIVE: The objective of our prospective monocentric work was to determine the diagnostic value of real-time elastography (RTE) in the assessment of liver fibrosis in patients with iron overload, using transient elastography (TE) as reference standard. METHODS: Sixty-seven consecutive patients with MRI detectable iron overload (T2*/=2 evaluated by AUC-ROC analysis was 0.798 (95% CI 0.674-0.890). The diagnostic accuracy of RTE for F>/=3 was 0.909 (95% CI 0.806-0.968). At a cut-off>/=2.75, RTE showed a sensitivity of 70% (95% CI 45.7-88.1) and a specificity of 97.5% (95% CI 86.8-99.9). CONCLUSIONS: In patients with MRI-detectable liver iron-overload RTE allows to discriminate between F0/1-F2 and F3-F4 with a reasonable diagnostic accuracy.

Pubmed : 24050879