Diagnostic value of controlled attenuation parameter for liver steatosis in patients with chronic hepatitis B

2014 World Journal of Gastroenterology 20;30 (10585-10590)

AIM: To study the diagnostic value of controlled attenuation parameter (CAP), evaluated by transient elastography, for liver steatosis in patients with chronic hepatitis B (CHB). METHODS: Eighty-eight patients with CHB were enrolled in this study. All of the patients were subjected to transient elastography to determine CAP. These patients also underwent liver biopsy in the same period. Using liver biopsy as a reference, we determined receiver operating characteristic (ROC) curves for different endpoints. Areas under the ROC curves (AUCs) were used to evaluate the diagnostic importance of CAP for liver steatosis in patients with CHB. RESULTS: A positive correlation was observed between the AUCs of CAP and liver pathological stage (r = 0.582, P 0.05; r = 0. 068, P > 0.05). The mean CAP value at S0 was 209.59 +/- 41.25 dB/m, 223.84 +/- 35.28 dB/m at S1, 274.17 +/- 43.69 dB/m at S2, and 312.50 +/- 25.44 dB/m at S3. CAP values among S0, S1, S2, and S3 were significantly different (F = 17.79, P

Pubmed : 25132779