Diagnostic Accuracy of Controlled Attenuation Parameter for Detecting Hepatic Steatosis in Patients with Chronic Liver Disease

2017 GE Port J Gastroenterol 24;4 (161-168)

Introduction: Controlled attenuation parameter (CAP), measured by transient elastography, has been suggested as a noninvasive method for the detection and quantification of steatosis. We aimed to assess the accuracy of CAP to detect steatosis in patients with chronic liver disease (CLD) compared with liver histology and to evaluate factors that correlate with the CAP value. Methods: Patients with CLD who underwent liver biopsy and simultaneous CAP determination were consecutively enrolled. CAP was measured using the M probe of FibroScan(R) (Echosens, Paris, France). Histologically, steatosis was categorized as absent (S0: 66% of all hepatocytes). Results: We analyzed 159 patients with CLD (61% men, mean age 47.9 +/- 12.9 years). We found a positive correlation between CAP and steatosis in histology (rs = 0.869, p 25 (odds ratio [OR] 48.4, 95% confidence interval [CI] 23.78-72.95, p /=S1, >/=S2, and >/=S3 were 206.5, 232.5, and 282.5 dB/m, respectively. CAP performance was 0.822, 0.956, and 0.976 for diagnosing steatosis >/=S1, >/=S2, and >/=S3, respectively. Conclusions: CAP had an excellent diagnostic accuracy for the detection of steatosis in diverse CLD patients. A CAP value cutoff of /=S3 with an accuracy of 98%.