Cross-validation of MR elastography and ultrasound transient elastography in liver stiffness measurement: discrepancy in the results of cirrhotic liver

2012 Journal of Magnetic Resonance Imaging 35;3 (607-610)

PURPOSE: To evaluate individual differences in liver stiffness measurement using both MR elastography (MRE) and ultrasound transient elastography (UTE) in patients with chronic liver disease. MATERIALS AND METHODS: This study included 80 patients with chronic liver disease who underwent both UTE and MRE. MRE and UTE were performed using a pneumatic driver (60 Hz) and an ultrasound probe with a vibrator (50 Hz), respectively. Liver stiffness data measured using the two techniques (mu(UTE) and mu(MRE) ) were compared with respect to shear modulus. The patients were subdivided into four quartiles on the basis of average of the mu(UTE) and mu(MRE) values for each patient. RESULTS: The analysis of the 4 quartile groups revealed that mu(UTE) was significantly higher than mu(MRE) in the two most stiff liver groups: mu(UTE) versus mu(MRE) , 7.5 (1.2) versus 6.0 (0.72) kPa for the group with [mu(UTE) + mu(MRE) ]/2 of 5.6-8.0 kPa; 15.1(4.2) versus 6.7 (1.4) kPa for the group with >8.0 kPa. However, in the least stiff liver group (i.e., the group with [mu(UTE) + mu(MRE) ]/2