Correlation of Transient Elastography With Severity of Cystic Fibrosis-related Liver Disease

2017 Journal of Pediatric Gastroenterology and Nutritio 64;4 (505-511)

OBJECTIVES: The aim of the study was to evaluate whether liver stiffness measurement (LSM), determined by transient elastography, correlates with presence and severity of liver disease in children and young adults with cystic fibrosis (CF). METHODS: Subjects underwent LSM at routine CF visits. Presence and severity of cystic fibrosis liver disease (CFLD) was determined by clinical parameters. Subjects were classified as no CFLD, CFLD without portal hypertension (PHTN), and CFLD with PHTN. LSM was compared with aspartate aminotransferase/platelet ratio index (APRI) as a correlate to severity of CFLD. RESULTS: A total of 249 subjects (53% boys; mean age 14 +/- 7 years; 7 [3%]

Pubmed : 27782957