Correlation of connective tissue growth factor with liver stiffness measured by transient elastography in biliary atresia

2013 Hepatology Research 43;7 (795-800)

AIM: Biliary atresia (BA) is a neonatal liver disease defined as chronic progressive fibrotic obliteration of extrahepatic bile ducts. The objective of this study was to determine the association of serum connective tissue growth factor (CTGF) with clinical outcome and liver stiffness measurement. METHODS: Eighty-two BA patients post-Kasai operation and 28 healthy controls were recruited. BA patients were categorized into two groups based on their portal hypertension (PH) status. Serum CTGF levels were determined by enzyme-linked immunosorbent assay. Liver stiffness scores were measured by transient elastography. RESULTS: BA patients had greater CTGF levels (905.9 +/- 57.7 vs 238.3 +/- 23.5 pg/mL, P

Pubmed : 23186341