Comparison of transient elastography, serum markers and clinical signs for the diagnosis of compensated cirrhosis

2010 Journal of Gastroenterology & Hepatology 25;9 (1562-1568)

BACKGROUND AND AIMS: Non-invasive diagnosis of compensated cirrhosis is important. We therefore compared liver stiffness by transient elastography, APRI score, AST/ALT ratio, hyaluronic acid and clinical signs to determine which modality performed best at identifying compensated cirrhosis. METHODS: Patients undergoing evaluation at a single center were recruited and had clinical, serological, endoscopy, radiological imaging, liver stiffness measurement and liver biopsy. Patients were stratified into cirrhotic and non-cirrhotic. RESULTS: In 404 patients (124 cirrhosis), transient elastography was diagnostically superior to the other modalities yielding an AUC 0.9 +/- 0.04 compared with hyaluronic acid (AUC 0.81 +/- 0.04: P 12 kPa represents an important clinical measurement for the diagnosis of cirrhosis.

Pubmed : 20796156