Clinical predictors of liver fibrosis in patients with chronic hepatitis B virus infection from children to adults

2018 The Journal of Infectious Diseases In Press;

Background: This study aimed to elucidate predictors of liver fibrosis in chronic hepatitis B virus (HBV)-infected subjects. Methods: Transient elastography was performed to define liver fibrosis in 533 chronic HBV-infected patients at 30.72 +/- 0.57 years of age. Protein array was performed on serum samples and lysates of Huh7 cells transfected with HBV mutants; the results were confirmed by ELISA. Single nucleotide polymorphisms in the interleukin-1beta gene were examined chronic HBV-infected patients with and without liver fibrosis. Results: Male gender, > 18 years old, and serum alpha-fetoprotein level > 3.6 ng/mL were independent predictors of a liver stiffness measurement of >/= 7 kPa (P = 0.005, 0.019, and