A new 3p25 locus is associated with liver fibrosis progression in HIV/HCV co-infected patients

2016 Hepatology In press;

BACKGROUND: There is growing evidence that human genetic variants contribute to liver fibrosis in subjects with hepatitis C virus (HCV) mono-infection, but this aspect has been little investigated in patients co-infected with HCV and human immunodeficiency virus (HIV). We performed the first genome-wide association study (GWAS) of liver fibrosis progression in patients co-infected with HCV and HIV, using the well-characterized French ANRS CO13 HEPAVIH cohort. Liver fibrosis was assessed by elastography (FibroScan(R)) providing a quantitative fibrosis score. After quality control, GWAS was conducted on 289 Caucasian patients, for a total of 8,426,597 genotyped (Illumina Omni2.5 BeadChip) or reliably imputed SNPs. SNPs with p-values

Pubmed : 27339598