Transient elastography for the prediction of oxaliplatin-associated liver injury in colon cancer patients: a preliminary analysis

2008 Journal of Gastrointestinal Cancer 39, 1-4 (82-85)

OBJECTIVE: The prognosis of advanced colon cancer has improved significantly over the last decade since new chemotherapy regimens including oxaliplatin have been developed. However, oxaliplatin-induced liver injury and characterized hepatic hemostatic status can occur after chemotherapy. The assessment of this type of liver injury is often difficult. METHODS: Elastography (Fibroscan) was used to evaluate liver injury in five cases before and after 5-FU, leucovorin, and oxaliplatin combination (FOLFOX) treatment. RESULTS: A clear change was observed in the stiffness of liver after chemotherapy within 48 h, and the hepatic stiffness was normalized in most cases after 2 weeks. Among the five patients, one patient showed aberrant elevation after a FOLFOX treatment, and the patient showed liver injury pathologically. CONCLUSION: Elastography is a good tool for evaluating hepatic injury after FOLFOX treatment.

Pubmed : 19377909